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Louisville vs. Clemson prediction: Why Louisville is favored to win women's college basketball matchup [11/16/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Louisville vs Clemson predictions for college basketball Sunday.
Women's college basketball action continues on Sunday at 3:00PM ET as Louisville locks horns with Clemson at Littlejohn Coliseum.
Based on updated simulations, Dimers' new women's basketball model predicts Louisville as the most likely winner of the Louisville vs. Clemson game.
This article offers further insights into Sunday's matchup, including best bets and picks.
Louisville vs. Clemson prediction: Who will win?
Using powerful machine learning and data, we have simulated the result of Sunday's women's basketball game between Louisville and Clemson 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model gives Louisville a 57% chance of beating Clemson.
According to our model, the 127.5-point over/under has a 51% chance of staying under.
Louisville vs. Clemson odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Louisville | Clemson |
|---|---|---|
| Spread | -1.5 (-110) | +1.5 (-110) |
| Moneyline | -122 | +118 |
| Total | o127.5 (-108) | u127.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Louisville vs. Clemson picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville -1.5 | -110 |
| Moneyline | Louisville | -122 |
| Total | Under 127.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Louisville to win.
Louisville vs. Clemson game-day updates and essential details
Sunday's women's basketball action between Clemson and Louisville at Littlejohn Coliseum is scheduled to commence at 3:00PM ET.
- Who: Louisville vs. Clemson
- Date: Sunday, November 16, 2025
- Time: 3:00PM ET/12:00PM PT
- Venue: Littlejohn Coliseum
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Conclusion
We predict Louisville, with a 57% win probability, will likely beat Clemson on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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