Louisiana-Lafayette vs. Southern Miss prediction: Southern Miss favored to win men's college basketball matchup [12/18/2025]

Men's college basketball action continues on Thursday at 8:30 PM ET as Louisiana-Lafayette takes on the favored Southern Miss in men's college basketball action at Reed Green Coliseum.

Based on the latest simulations, Dimers' advanced college basketball model predicts Southern Miss as the most likely winner of the Louisiana-Lafayette vs. Southern Miss game.

This article offers a closer look at Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisiana-Lafayette vs. Southern Miss prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Thursday's NCAA basketball game between Louisiana-Lafayette and Southern Miss 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Southern Miss a 90% chance of beating Louisiana-Lafayette. Our predicted final score has Southern Miss winning 72-59.

According to our model, Southern Miss (-12.5) has a 51% chance of covering the spread, while the 131.5-point over/under has an equal 50-50 chance of hitting.

Louisiana-Lafayette vs. Southern Miss odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisiana-Lafayette vs. Southern Miss picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: