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Louisiana-Lafayette vs. Southern Miss prediction: Southern Miss favored to win men's college basketball matchup [12/18/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Louisiana-Lafayette vs Southern Miss predictions for college basketball Thursday.
Southern Miss will square off with Louisiana-Lafayette in men's college basketball action at Reed Green Coliseum on Thursday, beginning at 8:30 PM ET.
Based on the latest simulation results, Dimers' advanced college basketball model projects Southern Miss as the most likely winner of the Louisiana-Lafayette vs. Southern Miss game.
This article offers an expanded analysis of Thursday's matchup, including an expanded look at the predicted score, best bets and picks.
Louisiana-Lafayette vs. Southern Miss prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Thursday's NCAA basketball matchup between Louisiana-Lafayette and Southern Miss 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives Southern Miss a 92% chance of beating Louisiana-Lafayette. Our predicted final score has Southern Miss winning 72-59.
According to our model, Southern Miss (-11.5) has a 54% chance of covering the spread, while the 132.5-point over/under has a 52% chance of staying under.
Louisiana-Lafayette vs. Southern Miss odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Louisiana-Lafayette | Southern Miss |
|---|---|---|
| Spread | +11.5 (-102) | -11.5 (-110) |
| Moneyline | +625 | -800 |
| Total | o132.5 (-105) | u132.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Louisiana-Lafayette vs. Southern Miss picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern Miss -11.5 | -110 |
| Moneyline | Southern Miss | -800 |
| Total | Under 132.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Southern Miss to win.
Louisiana-Lafayette vs. Southern Miss game-day updates and essential details
Thursday's men's college basketball matchup between Southern Miss and Louisiana-Lafayette at Reed Green Coliseum is scheduled to start at 8:30 PM ET.
- Who: Louisiana-Lafayette vs. Southern Miss
- Date: Thursday, December 18, 2025
- Time: 8:30 PM ET/5:30PM PT
- Venue: Reed Green Coliseum
Conclusion
We predict Southern Miss, with a 92% win probability, will likely beat Louisiana-Lafayette on Thursday.
AI and automation have enhanced this article to quickly deliver accurate Louisiana-Lafayette vs. Southern Miss insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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