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Rams vs. Seahawks prediction: Seattle favored to win ‘TNF’ Week 16 [2025]

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Written by Jason Bevilacqua

Get Los Angeles Rams vs Seattle Seahawks predictions for NFL Thursday.

Los Angeles Rams-Seattle Seahawks Predictions and Game Preview.
Los Angeles Rams vs. Seattle Seahawks NFL prediction for Thursday, December 18, 2025.

The Seattle Seahawks will square off with the Los Angeles Rams in NFL Week 16 action at Lumen Field on Thursday, starting at 8:15 PM ET.

Based on the latest simulations, Dimers' proven NFL model predicts the Seahawks as the most likely winner of the Rams vs. Seahawks game.

This article offers further insights into this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Rams vs. Seahawks prediction: Who will win ‘Thursday Night Football’?

Since our Rams-Seahawks predictions earlier in the week, we have simulated the outcome of Thursday's NFL game between the Rams and Seahawks 10,000 times as part of our NFL predictions coverage.

Our famous predictive model currently gives the Seahawks a 55% chance of defeating the Rams in Week 16 of the NFL season. Our predicted final score has the Seahawks winning 22-20.

According to our model, the bookmakers have got it right, and the Rams and Seahawks each have a 50% chance of covering the spread, while the over/under total of 42.5 points has a 54% chance of going over.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 16 straight up picks.

Rams vs. Seahawks odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type Rams Seahawks
Spread +1.5 (-105) -1.5 (-105)
Moneyline +108 -122
Total o42.5 (-110) u42.5 (-108)

All odds are correct at the time of publication and are subject to change.

Rams vs. Seahawks picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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