Los Angeles Rams vs. San Francisco 49ers updated prediction featuring Davante Adams, Christian McCaffrey [Week 10, 2025]

Dimers' latest NFL predictions are live for San Francisco 49ers and Los Angeles Rams in Week 10, with our model giving the Rams a 64% of winning against the 49ers on Sunday.

This update builds on our early 49ers-Rams predictions, presenting fresh win probabilities, score projections, and TD predictions for Davante Adams, Christian McCaffrey, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Rams vs. 49ers page.

What's changed? LA Rams vs. San Francisco updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Rams vs. Niners matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Rams 64%, 49ers 36%
• Predicted Final Score: Rams 26-22 49ers
• Spread: Rams (-4.5) 46%, 49ers (+4.5) 54%
• Total Points (49.5): Over 50%, Under 50%

As of November 6, 2025, these Rams-49ers calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 10 highlight the top candidates to find the end zone in Rams-Niners on Sunday:

Los Angeles Rams

• Davante Adams: 49.9% probability
• Kyren Williams: 49.6% probability
• Puka Nacua: 49.4% probability

San Francisco 49ers

• Christian McCaffrey: 59.8% probability
• George Kittle: 37.4% probability
• Jauan Jennings: 29.0% probability

Rams vs. Niners latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Rams -4.5 (-110), 49ers +4.5 (-110)
• Moneyline: Rams -220, 49ers +185
• Total: Over/Under 49.5 (-110/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Rams vs. Niners Week 10 details

The NFL Week 10 matchup between the 49ers and Rams at Levi's Stadium is scheduled for November 9, 2025.

• Who: Los Angeles Rams vs. San Francisco 49ers
• Date: Sunday, November 9, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Levi's Stadium

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Conclusion

We predict the Rams, with a 64% win probability, will likely beat the 49ers in Week 10 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Rams vs. 49ers game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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