Los Angeles Rams vs. San Francisco 49ers: Experts release early Week 10 preview [2025]

The Los Angeles Rams and San Francisco 49ers will meet in Week 10 of the NFL season at Levi's Stadium on Sunday, November 9, 2025, starting at 4:25PM ET.

Early simulations from Dimers' trusted NFL model favor the Rams as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Rams vs. 49ers predictions page.

LA Rams vs. San Francisco early predictions

Leveraging trusted machine learning and analysis, we have simulated the Rams vs. Niners game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Rams 60%, 49ers 40%
• Predicted final score: Rams 26-23 49ers
• Spread: Rams (-3.5) 41%, 49ers (+3.5) 59%
• Total points (49.5): Over 50%, Under 50%

As of November 3, 2025, these Rams-49ers figures and predictions reflect the latest data and insights available.

Rams vs. Niners Week 10 details

The NFL Week 10 matchup between the 49ers and Rams at Levi's Stadium is scheduled for November 9, 2025.

• Who: Los Angeles Rams vs. San Francisco 49ers
• Date: Sunday, November 9, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Levi's Stadium

Rams vs. Niners opening odds

We've researched the best betting odds across America for this Week 10 game, which are listed here:

• Spread: Rams -3.5 (-105), 49ers +3.5 (-110)
• Moneyline: Rams -190, 49ers +162
• Total: Over/Under 49.5 (-110/-108)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 10 highlight the top candidates to score a TD in Rams-Niners in Week 10:

Los Angeles Rams

• Kyren Williams: 58.4% probability
• Davante Adams: 48.9% probability
• Puka Nacua: 41.8% probability

San Francisco 49ers

• Christian McCaffrey: 66.9% probability
• George Kittle: 39.8% probability
• Jauan Jennings: 31.1% probability

Rams vs 49ers player props

Kyren Williams is projected to lead rushing for the Rams, while Christian McCaffrey is expected to pace the 49ers on the ground.

In the receiving game, our projections favor the LA Rams' Puka Nacua and San Francisco's Jauan Jennings as the likely leaders for each team.

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Conclusion

We predict the Rams, with a 60% win probability, will likely beat the 49ers in Week 10 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Rams vs. 49ers game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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