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Los Angeles Rams vs. San Francisco 49ers: Experts release early Week 10 preview [2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get early predictions for the upcoming Rams vs 49ers NFL game.
The Los Angeles Rams and San Francisco 49ers will meet in Week 10 of the NFL season at Levi's Stadium on Sunday, November 9, 2025, starting at 4:25PM ET.
Early simulations from Dimers' trusted NFL model favor the Rams as the most likely winner of this matchup.
For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Rams vs. 49ers predictions page.
LA Rams vs. San Francisco early predictions
Leveraging trusted machine learning and analysis, we have simulated the Rams vs. Niners game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:
- Straight up win probabilities: Rams 60%, 49ers 40%
- Predicted final score: Rams 26-23 49ers
- Spread: Rams (-3.5) 41%, 49ers (+3.5) 59%
- Total points (49.5): Over 50%, Under 50%
As of November 3, 2025, these Rams-49ers figures and predictions reflect the latest data and insights available.
Rams vs. Niners Week 10 details
The NFL Week 10 matchup between the 49ers and Rams at Levi's Stadium is scheduled for November 9, 2025.
- Who: Los Angeles Rams vs. San Francisco 49ers
- Date: Sunday, November 9, 2025
- Time: 4:25PM ET/1:25PM PT
- Venue: Levi's Stadium
Rams vs. Niners opening odds
We've researched the best betting odds across America for this Week 10 game, which are listed here:
- Spread: Rams -3.5 (-105), 49ers +3.5 (-110)
- Moneyline: Rams -190, 49ers +162
- Total: Over/Under 49.5 (-110/-108)
Odds may continue to move—track live changes via our NFL odds page.
Anytime touchdown scorer predictions
Early NFL player projections for Week 10 highlight the top candidates to score a TD in Rams-Niners in Week 10:
Los Angeles Rams
- Kyren Williams: 58.4% probability
- Davante Adams: 48.9% probability
- Puka Nacua: 41.8% probability
San Francisco 49ers
- Christian McCaffrey: 66.9% probability
- George Kittle: 39.8% probability
- Jauan Jennings: 31.1% probability
Rams vs 49ers player props
Kyren Williams is projected to lead rushing for the Rams, while Christian McCaffrey is expected to pace the 49ers on the ground.
In the receiving game, our projections favor the LA Rams' Puka Nacua and San Francisco's Jauan Jennings as the likely leaders for each team.
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Conclusion
We predict the Rams, with a 60% win probability, will likely beat the 49ers in Week 10 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.
Enhanced by AI and automation, this article delivers quick, accurate insights on the Rams vs. 49ers game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Stay informed with the latest NFL news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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