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Lakers vs. Celtics prediction: Boston favored to win Friday's NBA game [12/5/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Los Angeles Lakers vs Boston Celtics predictions for NBA Friday.
The Boston Celtics will take on the Los Angeles Lakers in NBA action at TD Garden on Friday, starting at 7:00PM ET.
Based on the latest simulation results and today’s injury reports, Dimers' proven NBA model predicts the Celtics as the most likely winner of the Lakers vs. Celtics game.
This prediction follows the latest NBA Injury Report, which suggests the Celtics lineup will feature stars like Jaylen Brown, Derrick White and Payton Pritchard, while the Lakers will look to Austin Reaves, Deandre Ayton and Rui Hachimura.
Luka Doncic will not be on the court, with the superstar out for this one.
This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Lakers vs. Celtics prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the outcome of Friday's NBA matchup between the Lakers and Celtics 10,000 times as part of our NBA predictions coverage.
Our leading predictive model currently gives the Celtics a 73% chance of defeating the Lakers. Our predicted final score has the Celtics winning 116-109.
According to our model, the Lakers (+7.5) have a 57% chance of covering the spread, while the over/under total of 226.5 points has an equal 50-50 chance of hitting.
Lakers vs. Celtics odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Lakers | Celtics |
|---|---|---|
| Spread | +7.5 (-105) | -7.5 (-115) |
| Moneyline | +260 | -298 |
| Total | o226.5 (-115) | u226.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Lakers vs. Celtics picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Lakers +7.5 | -105 |
| Moneyline | Lakers | +260 |
| Total | Under 226.5 | -105 |
According to our best NBA bets for Friday, the top play to make on this game is Lakers +7.5 at the spread.
Lakers vs. Celtics player props
Looking for Lakers vs. Celtics NBA prop bets? We use the best information available to project how each team's leading players will perform at TD Garden.
Austin Reaves is expected to lead the Lakers with 26 points, 5 rebounds and 7 assists, while Jaylen Brown is projected to have 32 points, 7 rebounds and 5 assists for the Celtics.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.
Lakers prediction
Our model's projected player stats for the Lakers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Austin Reaves | 26 | 5 | 7 | 3 | 49 |
| Deandre Ayton | 16 | 10 | 2 | 0 | 35 |
| Rui Hachimura | 15 | 4 | 2 | 2 | 25 |
| Jake LaRavia | 11 | 5 | 3 | 2 | 25 |
| Dalton Knecht | 9 | 3 | 1 | 2 | 16 |
Celtics prediction
Projected points, rebounds, assists and three-pointers made for the Celtics:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jaylen Brown | 32 | 7 | 5 | 2 | 54 |
| Derrick White | 17 | 5 | 6 | 3 | 38 |
| P. Pritchard | 16 | 4 | 4 | 3 | 32 |
| Anfernee Simons | 13 | 2 | 3 | 2 | 23 |
| Josh Minott | 10 | 5 | 1 | 1 | 22 |
Lakers vs. Celtics game-day updates and essential details
Friday's matchup between the Celtics and Lakers at TD Garden is scheduled to start at 7:00PM ET.
- Who: Los Angeles Lakers vs. Boston Celtics
- Date: Friday, December 5, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: TD Garden
Conclusion
We predict the Celtics, with a 73% win probability, will likely beat the Lakers on Friday, with Jaylen Brown projected for a game-high 54 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Lakers vs. Celtics insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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