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Los Angeles Chargers vs. Dallas Cowboys updated prediction featuring Omarion Hampton, Javonte Williams [Week 16, 2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get new expert Chargers vs Cowboys predictions for Sunday's game.
Dimers' latest NFL predictions are live for Dallas Cowboys vs. Los Angeles Chargers in Week 16, with our model giving the Cowboys a 60% of winning.
As Sunday approaches, both teams have updated their injury reports. Some lineup calls are still undecided, and those could shape how each side approaches this cross-conference clash.
Since our early Cowboys-Chargers predictions, we’ve updated the win probabilities, score projections, and TD odds for Omarion Hampton, Javonte Williams, and others.
For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—head to our Chargers vs. Cowboys page.
What's changed? LA Chargers vs. Dallas updated predictions
Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Chargers vs. Cowboys matchup stacks up. Here are the updated forecasts:
- Straight Up Win Probabilities: Chargers 40%, Cowboys 60%
- Predicted Final Score: Chargers 23-26 Cowboys
- Spread: Chargers (+2.5) 50%, Cowboys (-2.5) 50%
- Total Points (49.5): Over 50%, Under 50%
As of December 18, 2025, these Chargers-Cowboys calculations reflect changes since our early-week simulation.
Anytime touchdown scorer predictions
New NFL player projections for Week 16 highlight the top candidates to find the end zone in Chargers-Cowboys on Sunday:
Los Angeles Chargers
- Omarion Hampton: 43.3% probability
- Ladd McConkey: 37.7% probability
- Quentin Johnston: 34.3% probability
Dallas Cowboys
- Javonte Williams: 54.8% probability
- CeeDee Lamb: 37.7% probability
- Malik Davis: 35.2% probability
Chargers vs. Cowboys latest odds
The best current odds from the top sportsbooks in the US:
- Spread: Chargers +2.5 (-112), Cowboys -2.5 (-105)
- Moneyline: Chargers +115, Cowboys -126
- Total: Over/Under 49.5 (-110/-105)
Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.
Chargers vs. Cowboys Week 16 details
The NFL Week 16 game between the Cowboys and Chargers at AT&T Stadium is scheduled for December 21, 2025.
- Who: Los Angeles Chargers vs. Dallas Cowboys
- Date: Sunday, December 21, 2025
- Time: 1:00 PM ET/10:00AM PT
- Venue: AT&T Stadium
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Conclusion
We predict the Cowboys, with a 60% win probability, will likely beat the Chargers in Week 16 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.
Enhanced by AI and automation, this article delivers quick, accurate insights on the Chargers vs. Cowboys matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NFL
Stay up-to-date with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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