Los Angeles Chargers vs. Dallas Cowboys: Experts release early Week 16 predictions [2025]

The Los Angeles Chargers and Dallas Cowboys will meet in Week 16 of the NFL season at AT&T Stadium on Sunday, December 21, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Cowboys as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Chargers vs. Cowboys predictions page.

LA Chargers vs. Dallas early predictions

Leveraging trusted machine learning and analysis, we have simulated the Chargers vs. Cowboys game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Chargers 43%, Cowboys 57%
• Predicted final score: Chargers 23-25 Cowboys
• Spread: Chargers (+1.5) 47%, Cowboys (-1.5) 53%
• Total points (48.5): Over 50%, Under 50%

As of December 15, 2025, these Chargers-Cowboys numbers and predictions reflect the latest data and insights available.

Chargers vs. Cowboys Week 16 details

The NFL Week 16 matchup between the Cowboys and Chargers at AT&T Stadium is scheduled for December 21, 2025.

• Who: Los Angeles Chargers vs. Dallas Cowboys
• Date: Sunday, December 21, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: AT&T Stadium

Chargers vs. Cowboys opening odds

We've researched the best betting odds across America for this Week 16 game, which are listed here:

• Spread: Chargers +1.5 (-110), Cowboys -1.5 (-110)
• Moneyline: Chargers +130, Cowboys -135
• Total: Over/Under 48.5 (-110/-105)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cowboys, with a 57% win probability, will likely beat the Chargers in Week 16 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chargers vs. Cowboys game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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