Lipscomb vs. Duke prediction: Duke favored to win men's college basketball matchup [12/16/2025]

Duke will take on Lipscomb in men's college basketball action at Cameron Indoor Stadium on Tuesday, starting at 6:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Duke as the most likely winner of the Lipscomb vs. Duke game.

This article offers further insights into Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Lipscomb vs. Duke prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Tuesday's NCAA basketball matchup between Lipscomb and Duke 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Duke a 99% chance of defeating Lipscomb. Our predicted final score has Duke winning 91-62.

According to our model, Lipscomb (+33.5) has a 56% chance of covering the spread, while the over/under total of 152.5 points has a 52% chance of staying under.

Lipscomb vs. Duke odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Lipscomb vs. Duke picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: