Lafayette vs. Pennsylvania prediction: Why Pennsylvania is favored to win men's college basketball matchup [12/8/2025]

Pennsylvania will face Lafayette in men's college basketball action at The Palestra on Monday, commencing at 6:00PM ET.

Based on the latest simulations, Dimers' advanced college basketball model projects Pennsylvania as the most likely winner of the Lafayette vs. Pennsylvania game.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Lafayette vs. Pennsylvania prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Monday's NCAA basketball game between Lafayette and Pennsylvania 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Pennsylvania a 71% chance of defeating Lafayette. Our predicted final score has Pennsylvania winning 78-72.

According to our model, Lafayette (+7.5) has a 60% chance of covering the spread, while the over/under total of 151.5 points has a 52% chance of staying under.

Lafayette vs. Pennsylvania odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Lafayette vs. Pennsylvania picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: