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Kentucky vs. Louisville prediction: Louisville favored to win men's college basketball matchup [11/11/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Kentucky vs Louisville predictions for college basketball Tuesday.
Louisville will square off with Kentucky in men's college basketball action at KFC Yum! Center on Tuesday, starting at 8:00PM ET.
Based on updated simulation results, Dimers' advanced college basketball model predicts Louisville as the most likely winner of the Kentucky vs. Louisville game.
This article offers further insights into Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.
Kentucky vs. Louisville prediction: Who will win, cover the spread?
Using innovative machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball matchup between Kentucky and Louisville 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model currently gives Louisville a 71% chance of beating Kentucky. Our predicted final score has Louisville winning 84-78.
According to our model, Kentucky (+6.5) has a 51% chance of covering the spread, while the over/under total of 173.5 points has a 56% chance of staying under.
Kentucky vs. Louisville odds
We have sourced the best Men's College Basketball odds in America for this game, which are listed here:
| Bet Type | Kentucky | Louisville |
|---|---|---|
| Spread | +6.5 (-112) | -6.5 (-102) |
| Moneyline | +230 | -250 |
| Total | o173.5 (-105) | u173.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Kentucky vs. Louisville picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville -6.5 | -102 |
| Moneyline | Louisville | -250 |
| Total | Under 173.5 | -105 |
According to our best men's college basketball bets, the top play to make on this game is Under 173.5 total points.
Kentucky vs. Louisville game-day updates and essential details
Tuesday's men's college basketball action between Louisville and Kentucky at KFC Yum! Center is scheduled to start at 8:00PM ET.
- Who: Kentucky vs. Louisville
- Date: Tuesday, November 11, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict Louisville, with a 71% win probability, will likely beat Kentucky on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate Kentucky vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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