Kansas City vs. Southern Illinois prediction: Southern Illinois favored to win men's college basketball matchup [11/7/2025]

Southern Illinois and Kansas City will meet in men's college basketball action at Banterra Center on Friday, with tipoff at 8:00PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts Southern Illinois as the most likely winner of the Kansas City vs. Southern Illinois game.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Kansas City vs. Southern Illinois prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Friday's NCAA basketball game between Kansas City and Southern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Southern Illinois an 87% chance of defeating Kansas City. Our predicted final score has Southern Illinois winning 79-66.

According to our model, Kansas City (+12.5) has a 51% chance of covering the spread, while the 141.5-point over/under has a 56% chance of going over.

Kansas City vs. Southern Illinois odds

We have researched the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Kansas City vs. Southern Illinois picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Over 141.5 total points.

Kansas City vs. Southern Illinois game-day updates and essential details

Friday's men's college basketball game between Southern Illinois and Kansas City at Banterra Center is scheduled to commence at 8:00PM ET.

• Who: Kansas City vs. Southern Illinois
• Date: Friday, November 7, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Banterra Center

Conclusion

We predict Southern Illinois, with an 87% win probability, will likely beat Kansas City on Friday.

AI and automation have enhanced this article to quickly deliver accurate Kansas City vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on men's college basketball

Keep up with the latest men's college basketball news and CBB parlay picks throughout the season. Plus, our NCAA Tournament Championship odds offer the latest projections for every March Madness contender.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.