James Madison vs. Old Dominion prediction: James Madison favored to win men's college basketball matchup [12/17/2025]

Old Dominion and James Madison are scheduled to meet in men's college basketball action at Chartway Arena on Wednesday, with tipoff at 8:00 PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts James Madison as the most likely winner of the James Madison vs. Old Dominion game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

James Madison vs. Old Dominion prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between James Madison and Old Dominion 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives James Madison a 61% chance of defeating Old Dominion. Our predicted final score has James Madison winning 75-72.

According to our model, James Madison (-2.5) has a 51% chance of covering the spread, while the 146.5-point over/under has a 52% chance of going over.

James Madison vs. Old Dominion odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

James Madison vs. Old Dominion picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: