James Madison vs. Old Dominion prediction: James Madison favored to win men's college basketball matchup [12/17/2025]

Old Dominion will face James Madison in men's college basketball action at Chartway Arena on Wednesday, beginning at 8:00 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts James Madison as the most likely winner of the James Madison vs. Old Dominion game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

James Madison vs. Old Dominion prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball matchup between James Madison and Old Dominion 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives James Madison a 61% chance of defeating Old Dominion. Our predicted final score has James Madison winning 75-72.

According to our model, James Madison (-2.5) has a 51% chance of covering the spread, while the over/under total of 148.5 points has an equal 50-50 chance of hitting.

James Madison vs. Old Dominion odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

James Madison vs. Old Dominion picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is James Madison to win.

James Madison vs. Old Dominion game-day updates and essential details

Wednesday's men's college basketball game between Old Dominion and James Madison at Chartway Arena is scheduled to begin at 8:00 PM ET.

• Who: James Madison vs. Old Dominion
• Date: Wednesday, December 17, 2025
• Time: 8:00 PM ET/5:00PM PT
• Venue: Chartway Arena

Conclusion

We predict James Madison, with a 61% win probability, will likely beat Old Dominion on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate James Madison vs. Old Dominion insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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