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Jacksonville Jaguars vs. Indianapolis Colts updated prediction featuring Travis Etienne, Jonathan Taylor [Week 17, 2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get new expert Jaguars vs Colts predictions for Sunday's game.
Dimers' latest NFL predictions are live for Indianapolis Colts vs. Jacksonville Jaguars in Week 17, with our model giving the Jaguars a 68% of winning.
As Sunday approaches, both teams have updated their injury reports. Some lineup calls are still undecided, and those could shape how each side approaches this AFC South matchup.
Since our early Colts-Jaguars predictions, we’ve updated the win probabilities, score projections, and TD odds for Travis Etienne, Jonathan Taylor, and others.
For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—head to our Jaguars vs. Colts page.
What's changed? Jacksonville vs. Indianapolis updated predictions
Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Jaguars vs. Colts matchup stacks up. Here are the updated forecasts:
- Straight Up Win Probabilities: Jaguars 68%, Colts 32%
- Predicted Final Score: Jaguars 27-21 Colts
- Spread: Jaguars (-6.5) 43%, Colts (+6.5) 57%
- Total Points (48.5): Over 53%, Under 47%
As of December 25, 2025, these Jaguars-Colts figures reflect changes since our early-week simulation.
Anytime touchdown scorer predictions
New NFL player projections for Week 17 highlight the top candidates to find the end zone in Jaguars-Colts on Sunday:
Jacksonville Jaguars
- Travis Etienne: 57.6% probability
- Jakobi Meyers: 33.3% probability
- Brian Thomas: 31.0% probability
Indianapolis Colts
- Jonathan Taylor: 61.9% probability
- Tyler Warren: 28.9% probability
- Michael Pittman: 25.9% probability
Jaguars vs. Colts latest odds
The best current odds from the top sportsbooks in the US:
- Spread: Jaguars -6.5 (-108), Colts +6.5 (-105)
- Moneyline: Jaguars -278, Colts +240
- Total: Over/Under 48.5 (-110/-110)
Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.
Jaguars vs. Colts Week 17 details
The NFL Week 17 matchup between the Colts and Jaguars at Lucas Oil Stadium is scheduled for December 28, 2025.
- Who: Jacksonville Jaguars vs. Indianapolis Colts
- Date: Sunday, December 28, 2025
- Time: 1:00 PM ET/10:00AM PT
- Venue: Lucas Oil Stadium
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Conclusion
We predict the Jaguars, with a 68% win probability, will likely beat the Colts in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.
Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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