Jacksonville Jaguars vs. Indianapolis Colts updated prediction featuring Travis Etienne, Jonathan Taylor [Week 17, 2025]

Dimers' latest NFL predictions are live for Indianapolis Colts vs. Jacksonville Jaguars in Week 17, with our model giving the Jaguars a 68% of winning.

As Sunday approaches, both teams have updated their injury reports. Some lineup calls are still undecided, and those could shape how each side approaches this AFC South matchup.

Since our early Colts-Jaguars predictions, we’ve updated the win probabilities, score projections, and TD odds for Travis Etienne, Jonathan Taylor, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—head to our Jaguars vs. Colts page.

What's changed? Jacksonville vs. Indianapolis updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Jaguars vs. Colts matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Jaguars 68%, Colts 32%
• Predicted Final Score: Jaguars 27-21 Colts
• Spread: Jaguars (-6.5) 43%, Colts (+6.5) 57%
• Total Points (48.5): Over 53%, Under 47%

As of December 25, 2025, these Jaguars-Colts figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 17 highlight the top candidates to find the end zone in Jaguars-Colts on Sunday:

Jacksonville Jaguars

• Travis Etienne: 57.6% probability
• Jakobi Meyers: 33.3% probability
• Brian Thomas: 31.0% probability

Indianapolis Colts

• Jonathan Taylor: 61.9% probability
• Tyler Warren: 28.9% probability
• Michael Pittman: 25.9% probability

Jaguars vs. Colts latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Jaguars -6.5 (-108), Colts +6.5 (-105)
• Moneyline: Jaguars -278, Colts +240
• Total: Over/Under 48.5 (-110/-110)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Jaguars vs. Colts Week 17 details

The NFL Week 17 matchup between the Colts and Jaguars at Lucas Oil Stadium is scheduled for December 28, 2025.

• Who: Jacksonville Jaguars vs. Indianapolis Colts
• Date: Sunday, December 28, 2025
• Time: 1:00 PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

NFL Week 17 betting promos and codes

Make the most of Dimers' Jaguars vs. Colts predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Jaguars, with a 68% win probability, will likely beat the Colts in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay up-to-date with the latest NFL betting news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.