Jacksonville Jaguars vs. Indianapolis Colts: Experts release early Week 17 projections [2025]

The Jacksonville Jaguars and Indianapolis Colts will meet in Week 17 of the NFL season at Lucas Oil Stadium on Sunday, December 28, 2025, starting at 1:00 PM ET.

Initial simulations from Dimers' trusted NFL model favor the Jaguars as the most likely winner of this AFC South rivalry matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Jaguars vs. Colts predictions page.

Jacksonville vs. Indianapolis early predictions

Leveraging trusted machine learning and analysis, we have simulated the Jaguars vs. Colts game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Jaguars 70%, Colts 30%
• Predicted final score: Jaguars 26-20 Colts
• Spread: Jaguars (-7) 40%, Colts (+7) 60%
• Total points (46.5): Over 54%, Under 46%

As of December 22, 2025, these Jaguars-Colts calculations and predictions reflect the latest data and insights available.

Jaguars vs. Colts Week 17 details

The NFL Week 17 action between the Colts and Jaguars at Lucas Oil Stadium is scheduled for December 28, 2025.

• Who: Jacksonville Jaguars vs. Indianapolis Colts
• Date: Sunday, December 28, 2025
• Time: 1:00 PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

Jaguars vs. Colts opening odds

We've researched the best betting odds across America for this Week 17 game, which are listed here:

• Spread: Jaguars -7 (-105), Colts +7 (-115)
• Moneyline: Jaguars -300, Colts +280
• Total: Over/Under 46.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 17 highlight the top candidates to score a TD in Jaguars-Colts in Week 17:

Jacksonville Jaguars

• Travis Etienne: 49.0% probability
• Trevor Lawrence: 30.2% probability
• Jakobi Meyers: 29.2% probability

Indianapolis Colts

• Jonathan Taylor: 70.5% probability
• Tyler Warren: 29.9% probability
• Josh Downs: 27.3% probability

Jaguars vs Colts player props

Travis Etienne is projected to lead rushing for the Jaguars, while Jonathan Taylor is expected to pace the Colts on the ground.

In the receiving game, our projections favor Jacksonville's Brian Thomas and Indianapolis' Tyler Warren as the likely leaders for each team.

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Conclusion

We predict the Jaguars, with a 70% win probability, will likely beat the Colts in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Colts matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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