Indiana vs. Ohio State prediction: Ohio State favored to win Big 10 Championship, 2025

Ohio State and Indiana will meet in the 2025 Big Ten Championship Game at Lucas Oil Stadium on Saturday, commencing at 8:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects Ohio State as the most likely winner of the Indiana vs. Ohio State game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Big Ten Football Championship Game prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Indiana vs. Ohio State 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Ohio State a 64% chance of beating Indiana. Our predicted final score has Ohio State winning 26-21.

According to our model, Ohio State (-3.5) has a 52% chance of covering the spread, while the 46.5-point over/under has an equal 50-50 chance of hitting.

Indiana vs. Ohio State odds

We have researched the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Indiana vs. Ohio State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: