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Indiana State vs. SIUE prediction: SIU-Edwardsville favored to win men's college basketball matchup [11/10/2025]

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Written by Mac Douglass

Get Indiana State vs SIUE predictions for college basketball Monday.

Indiana State-SIUE Predictions and Game Preview.
Indiana State vs. SIUE men's college basketball prediction for Monday, November 10, 2025.

Men's college basketball action continues on Monday at 7:00PM ET as Indiana State squares off with SIUE in men's college basketball action at Sam M. Vadalabene Center.

Based on the latest simulations, Dimers' proven college basketball model predicts SIU-Edwardsville as the most likely winner of the Indiana State vs. SIUE game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Indiana State vs. SIUE prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the result of Monday's NCAA basketball matchup between Indiana State and SIUE 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives SIU-Edwardsville a 59% chance of beating Indiana State. Our predicted final score has SIU-Edwardsville winning 79-77.

According to our model, the bookmakers have got it right, and Indiana State and SIU-Edwardsville each have a 50% chance of covering the spread, while the 159.5-point over/under has a 53% chance of staying under.

 

Indiana State vs. SIUE odds

We have sourced the best Men's College Basketball odds in America for this game, which are listed here:

Bet Type Indiana State SIUE
Spread +2.5 (-108) -2.5 (-105)
Moneyline +116 -135
Total o159.5 (-105) u159.5 (-112)

All odds are correct at the time of publication and are subject to change.

Indiana State vs. SIUE picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Indiana State +2.5 -108
Moneyline SIU-Edwardsville -135
Total Under 159.5 -112

According to our men's college basketball best bets, the top play to make on this game is SIU-Edwardsville to win.

 

Indiana State vs. SIUE game-day updates and essential details

Monday's men's college basketball matchup between SIUE and Indiana State at Sam M. Vadalabene Center is scheduled to start at 7:00PM ET.

  • Who: Indiana State vs. SIU-Edwardsville
  • Date: Monday, November 10, 2025
  • Time: 7:00PM ET/4:00PM PT
  • Venue: Sam M. Vadalabene Center

Conclusion

We predict SIU-Edwardsville, with a 59% win probability, will likely beat Indiana State on Monday.

AI and automation have enhanced this article to quickly deliver accurate Indiana State vs. SIU-Edwardsville insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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