Illinois vs. Duke Prediction: Duke Predicted to Win College Basketball Matchup [2/22/2025]

Duke and Illinois will lock horns in college basketball action at Madison Square Garden on Saturday, starting at 8:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model (see Dimers Pro for full access) projects Duke as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Our team has used the latest data to run 10,000 simulations of Saturday's Illinois-Duke game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that Duke is more likely to win, while Illinois has a lower chance of victory."

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Illinois vs. Duke predictions page.

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Illinois vs. Duke Prediction: Who Will Win, Cover the Spread?

Using trusted machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Illinois and Duke 10,000 times as part of our college basketball predictions coverage.

Our leading predictive model gives Duke an 80% chance of beating Illinois. Our predicted final score has Duke winning 82-72.

According to our model, Duke (-8.5) has a 55% chance of covering the spread, while the 156.5-point over/under has a 54% chance of staying under.

Illinois vs. Duke Odds

We have sourced the best College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Illinois vs. Duke Picks and Best Bets

Our model's strongest edge in today's Illinois vs. Duke matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Illinois vs. Duke Game-Day Updates and Essential Details

Saturday's college basketball action between Duke and Illinois at Madison Square Garden is scheduled to start at 8:00PM ET.

• Who: Illinois vs. Duke
• Date: Saturday, February 22, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Madison Square Garden

Dimers.com's in-depth preview of Saturday's Illinois vs. Duke matchup includes our prediction, picks and the latest betting odds.

Before making any Illinois vs. Duke picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

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Conclusion

We predict Duke, with an 80% win probability, will likely beat Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Illinois vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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