Illinois State vs. Southern Illinois prediction: Southern Illinois favored to win men's college basketball matchup [12/18/2025]

Southern Illinois will face Illinois State in men's college basketball action at Banterra Center on Thursday, beginning at 9:00 PM ET.

Based on the latest simulations, Dimers' proven college basketball model predicts Southern Illinois as the most likely winner of the Illinois State vs. Southern Illinois game.

This article offers further insights into Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Illinois State vs. Southern Illinois prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Thursday's NCAA basketball matchup between Illinois State and Southern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Southern Illinois a 55% chance of beating Illinois State. Our predicted final score has Southern Illinois winning 76-75.

According to our model, the bookmakers have got it right, and Illinois State and Southern Illinois each have a 50% chance of covering the spread, while the 154.5-point over/under has a 53% chance of staying under.

Illinois State vs. Southern Illinois odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Illinois State vs. Southern Illinois picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: