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Houston Dynamo vs. San Diego FC prediction, odds, MLS picks [4/22/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Houston Dynamo vs San Diego FC predictions for MLS Wednesday.
Houston will face San Diego FC in MLS action at Shell Energy Stadium on Wednesday, commencing at 8:30 PM ET.
Based on the latest simulation results, Dimers' advanced MLS model predicts Houston as the most likely winner of the Houston vs. San Diego FC game.
This article offers further insights into Wednesday's match, including best bets and picks.
Houston Dynamo vs. San Diego FC prediction: Who will win?
Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLS matchup between Houston and San Diego FC, forming part of our MLS predictions coverage.
Our famous predictive model currently indicates a 47.7% chance of Houston winning, a 28.6% chance for San Diego FC, and a 23.8% chance of a draw.
Additionally, the 2.5-goal over/under has a 57% chance of going over, according to our model.
Houston Dynamo vs. San Diego FC odds
We have sourced the best MLS odds in America for this game, which are listed here:
Moneyline
| Houston | San Diego FC | Draw |
|---|---|---|
| -102 | +240 | +290 |
Total Goals
| Over 2.5 | Under 2.5 |
|---|---|
| -185 | +125 |
All odds are correct at the time of publication and are subject to change.
Houston Dynamo vs. San Diego FC picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | San Diego FC | +240 |
| Total Goals | Under 2.5 | +125 |
According to our best MLS bets, the top play to make on this game is San Diego FC to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Houston Dynamo vs. San Diego FC: Correct score predictions
Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:
| Final Score | Probability |
|---|---|
| HOU 1-1 San Diego FC | 11% |
| HOU 2-1 San Diego FC | 9.4% |
| HOU 1-0 San Diego FC | 8.7% |
These predictions are based on each team's average score according to our machine learning model, which means the most likely correct score can differ from our predicted winner.
Houston Dynamo vs. San Diego FC game-day updates and essential details
Wednesday's matchup between Houston and San Diego FC in MLS at Shell Energy Stadium is scheduled to begin at 8:30 PM ET.
- Who: Houston Dynamo vs. San Diego FC
- Date: Wednesday, April 22, 2026
- Time: 8:30 PM ET/5:30PM PT
- Venue: Shell Energy Stadium
Conclusion
According to our computer model, Houston has a 47.7% win probability on Wednesday, San Diego FC has a 28.6% win probability, and there is a 23.8% chance that the game will end in a draw.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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