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Astros vs. White Sox Prediction: Houston Predicted to Win Sunday's MLB Matchup [5/4/2025]
Our expert prediction for Sunday's Houston Astros vs Chicago White Sox matchup.

The Chicago White Sox and Houston Astros will meet in MLB action at Rate Field on Sunday, starting at 2:10PM ET.
The White Sox will have Bryse Wilson (0-1, 5.00 ERA) as their starting pitcher, while the Astros have opted for Lance McCullers (0-0, 0.00 ERA).
Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Houston-CHI White Sox game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Astros with a win probability of 66%, while the White Sox have 34%."
For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Astros vs. White Sox predictions page.
White Sox vs. Astros Prediction: Who Will Win, Cover the Run Line?
Using trusted machine learning and statistical analysis, we have simulated the result of Sunday's MLB game between the Astros and White Sox 10,000 times as part of our MLB predictions coverage.
Our famous predictive model gives the Astros a 66% chance of beating the White Sox.
According to our model, the Astros (-1.5) have a 53% chance of covering the run line, while the 8-run over/under has a 54% chance of going over.
Astros vs. White Sox Odds [5/4/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
Bet Type | Astros | White Sox |
---|---|---|
Run Line | -1.5 (+102) | +1.5 (-110) |
Moneyline | -172 | +150 |
Total | o8 (-115) | u8 (-102) |
All odds are correct at the time of publication and are subject to change.
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Astros vs. White Sox Picks and Best Bets
Our model's strongest edge in today's Astros vs. White Sox matchup is on the total.
Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free MLB Picks
Calling Our Shot produces daily MLB betting content, including the best bets featured below.
Astros vs. White Sox Game-Day Updates and Essential Details
Sunday's MLB matchup between the White Sox and Astros at Rate Field is scheduled to begin at 2:10PM ET.
- Who: Houston Astros vs. Chicago White Sox
- Date: Sunday, May 4, 2025
- Time: 2:10PM ET/11:10AM PT
- Venue: Rate Field
Dimers.com's in-depth preview of Sunday's Astros vs. White Sox matchup includes our prediction, picks and the latest betting odds.
Before making any Houston vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion
We predict the Astros, with a 66% win probability, will likely beat the White Sox on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Astros vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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