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Astros vs. White Sox Prediction: Houston Predicted to Win Sunday's MLB Matchup [5/4/2025]

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Written by Jason Bevilacqua

Our expert prediction for Sunday's Houston Astros vs Chicago White Sox matchup.

Houston Astros-Chicago White Sox Predictions and Game Preview.
Rate Field sets the stage for the MLB matchup between the Houston Astros and Chicago White Sox this Sunday.

The Chicago White Sox and Houston Astros will meet in MLB action at Rate Field on Sunday, starting at 2:10PM ET.

The White Sox will have Bryse Wilson (0-1, 5.00 ERA) as their starting pitcher, while the Astros have opted for Lance McCullers (0-0, 0.00 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Houston-CHI White Sox game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Astros with a win probability of 66%, while the White Sox have 34%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Astros vs. White Sox predictions page.

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White Sox vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Sunday's MLB game between the Astros and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Astros a 66% chance of beating the White Sox.

According to our model, the Astros (-1.5) have a 53% chance of covering the run line, while the 8-run over/under has a 54% chance of going over.

Pre-Game Probabilities
Last Updated: 6:27PM, May 4
Moneyline
Over / Under
Run Line
Astros
Win %
66%
34%
Get the best bets with Dimers Pro
See Matchup
White Sox
Astros HOU
Win %
66%
34%
See Matchup
White Sox CWS
Lance McCullers 0-0, 0.00 ERA
Bryse Wilson 0-1, 5.00 ERA
Get the best bets with Dimers Pro

Astros vs. White Sox Odds [5/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type Astros White Sox
Run Line -1.5 (+102) +1.5 (-110)
Moneyline -172 +150
Total o8 (-115) u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Astros vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Astros vs. White Sox matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Astros vs. White Sox Game-Day Updates and Essential Details

Sunday's MLB matchup between the White Sox and Astros at Rate Field is scheduled to begin at 2:10PM ET.

Dimers.com's in-depth preview of Sunday's Astros vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict the Astros, with a 66% win probability, will likely beat the White Sox on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date projections for the World Series, American League, National League and each division.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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