Holy Cross vs. Lafayette prediction: Holy Cross favored to win men's college basketball matchup [1/17/2026]

Lafayette and Holy Cross are scheduled to meet in men's college basketball action at Kirby Sports Center on Saturday, starting at 1:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model projects Holy Cross as the most likely winner of the Holy Cross vs. Lafayette game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Holy Cross vs. Lafayette prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the result of Saturday's NCAA basketball game between Holy Cross and Lafayette 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Holy Cross a 71% chance of defeating Lafayette. Our predicted final score has Holy Cross winning 71-66.

According to our model, Holy Cross (-4.5) has a 56% chance of covering the spread, while the 137.5-point over/under has a 52% chance of going over.

Holy Cross vs. Lafayette odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Holy Cross vs. Lafayette picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: