Holy Cross vs. American University prediction: Why American University is favored to win men's college basketball matchup [1/10/2026]

Men's college basketball action continues on Saturday at 4:00 PM ET as Holy Cross takes on the favored American University in men's college basketball action at Bender Arena.

Based on updated simulation results, Dimers' advanced college basketball model predicts American University as the most likely winner of the Holy Cross vs. American University game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Holy Cross vs. American University prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Saturday's NCAA basketball matchup between Holy Cross and American University 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives American University an 83% chance of defeating Holy Cross. Our predicted final score has American University winning 74-65.

According to our model, American University (-8.5) has a 55% chance of covering the spread, while the over/under total of 137.5 points has a 53% chance of going over.

Holy Cross vs. American University odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Holy Cross vs. American University picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: