Grambling State vs. Southern Miss prediction: Southern Miss favored to win men's college basketball matchup [12/8/2025]

Southern Miss and Grambling State will lock horns in men's college basketball action at Reed Green Coliseum on Monday, starting at 8:00PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Southern Miss as the most likely winner of the Grambling State vs. Southern Miss game.

This article offers a closer look at Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Grambling State vs. Southern Miss prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Monday's NCAA basketball game between Grambling State and Southern Miss 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Southern Miss a 77% chance of defeating Grambling State. Our predicted final score has Southern Miss winning 75-67.

According to our model, the bookmakers have got it right, and Grambling State and Southern Miss each have a 50% chance of covering the spread, while the 142.5-point over/under has a 53% chance of going over.

Grambling State vs. Southern Miss odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Grambling State vs. Southern Miss picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: