Gonzaga vs. San Francisco prediction: Gonzaga favored to win men's college basketball matchup [2/18/2026]

San Francisco will take on the favored Gonzaga in men's college basketball action at Chase Center on Wednesday, commencing at 11:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Gonzaga as the most likely winner of the Gonzaga vs. San Francisco game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Gonzaga vs. San Francisco prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between Gonzaga and San Francisco 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Gonzaga an 88% chance of beating San Francisco. Our predicted final score has Gonzaga winning 82-69.

According to our model, San Francisco (+15.5) has a 56% chance of covering the spread, while the 151.5-point over/under has an equal 50-50 chance of hitting.

Gonzaga vs. San Francisco odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Gonzaga vs. San Francisco picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: