Gonzaga vs. Oregon prediction: Gonzaga favored to win men's college basketball matchup [12/21/2025]

Oregon will take on the favored Gonzaga in men's college basketball action at Moda Center on Sunday, starting at 6:00 PM ET.

Based on the latest simulations, Dimers' proven college basketball model projects Gonzaga as the most likely winner of the Gonzaga vs. Oregon game.

This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Gonzaga vs. Oregon prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the result of Sunday's NCAA basketball matchup between Gonzaga and Oregon 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Gonzaga an 80% chance of beating Oregon. Our predicted final score has Gonzaga winning 82-72.

According to our model, Oregon (+11.5) has a 56% chance of covering the spread, while the over/under total of 157.5 points has a 53% chance of staying under.

Gonzaga vs. Oregon odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Gonzaga vs. Oregon picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: