FC Cincinnati vs. Columbus Crew prediction, odds, MLS Cup first round picks [11/8/2025]

MLS Cup action continues on Saturday at 6:00PM ET as Columbus squares off with Cincinnati in the first round at TQL Stadium.

Based on updated simulations, Dimers' proven MLS model predicts Cincinnati as the most likely winner of the Cincinnati vs. Columbus game.

This article offers further insights into Saturday's matchup, including best bets and picks.

FC Cincinnati vs. Columbus Crew prediction: Who will win MLS Cup first round matchup?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLS matchup between Cincinnati and Columbus 10,000 times as part of our MLS predictions coverage.

Our independent predictive model currently indicates a 45.4% chance of Cincinnati winning, a 31.2% chance for Columbus, and a 23.5% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 60% chance of going over, according to our model.

FC Cincinnati vs. Columbus Crew - MLS Cup first round odds

We have sourced the best MLS odds in America for this game, which are listed here:

Moneyline

Total Goals

All odds are correct at the time of publication and are subject to change.

FC Cincinnati vs. Columbus Crew picks and best bet for MLS Cup first round

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our MLS best bets, the top play to make on this game is Cincinnati to win.

FC Cincinnati vs. Columbus Crew: Correct score predictions

The top three most likely final scores, according to our model, are listed below, with a 1-1 draw being the most probable:

These predictions are based on each team's average score after 10,000 simulations, which means the most likely correct score may differ from our predicted winner.

FC Cincinnati vs. Columbus Crew MLS Cup first round updates and essential details

Saturday's matchup between Cincinnati and Columbus in MLS at TQL Stadium is scheduled to begin at 6:00PM ET.

• Who: FC Cincinnati vs. Columbus Crew
• Date: Saturday, November 8, 2025
• Time: 6:00PM ET/3:00PM PT
• Venue: TQL Stadium

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Conclusion

According to our computer model, Cincinnati has a 45.4% win probability on Saturday, Columbus has a 31.2% win probability, and there is a 23.5% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Cincinnati vs. Columbus insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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