Eastern Illinois vs. Southern Indiana prediction: Southern Indiana favored to win men's college basketball matchup [1/22/2026]

Southern Indiana will face Eastern Illinois in men's college basketball action at Liberty Arena on Thursday, commencing at 8:30 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Southern Indiana as the most likely winner of the Eastern Illinois vs. Southern Indiana game.

This article offers a closer look at Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Eastern Illinois vs. Southern Indiana prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Thursday's NCAA basketball game between Eastern Illinois and Southern Indiana 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Southern Indiana a 59% chance of defeating Eastern Illinois. Our predicted final score has Southern Indiana winning 70-67.

According to our model, Eastern Illinois (+2.5) has a 51% chance of covering the spread, while the 135.5-point over/under has a 54% chance of going over.

Eastern Illinois vs. Southern Indiana odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Eastern Illinois vs. Southern Indiana picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Over 135.5 total points.

Eastern Illinois vs. Southern Indiana game-day updates and essential details

Thursday's men's college basketball matchup between Southern Indiana and Eastern Illinois at Liberty Arena is scheduled to begin at 8:30 PM ET.

• Who: Eastern Illinois vs. Southern Indiana
• Date: Thursday, January 22, 2026
• Time: 8:30 PM ET/5:30PM PT
• Venue: Liberty Arena

Conclusion

We predict Southern Indiana, with a 59% win probability, will likely beat Eastern Illinois on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Eastern Illinois vs. Southern Indiana insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.