Duke vs. Syracuse Prediction: Duke Predicted to Win College Basketball Matchup [2/5/2025]

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Written by Mac Douglass

Our expert prediction for Wednesday's Duke vs Syracuse matchup.

Duke-Syracuse Predictions and Game Preview.
JMA Wireless Dome sets the stage for the college basketball matchup between Duke and Syracuse this Wednesday.

College basketball action continues on Wednesday at 7:00PM ET as the favored Duke takes on Syracuse in college basketball action at JMA Wireless Dome.

Based on the latest simulations, Dimers' proven college basketball model (see Dimers Pro for full access) predicts Duke as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Duke-Syracuse game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate Duke's chance of winning at 94%, with Syracuse at 6%."

For expanded analysis of Wednesday's matchup, including the predicted score, best bets and an expanded look at the predicted final score, visit our interactive Duke vs. Syracuse predictions page.

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Duke vs. Syracuse Prediction: Who Will Win, Cover the Spread?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Duke and Syracuse 10,000 times as part of our college basketball predictions coverage.

Our independent predictive model currently gives Duke a 94% chance of defeating Syracuse. Our predicted final score has Duke winning 81-64.

According to our model, the bookies have got it right, and Duke and Syracuse each have a 50% chance of covering the spread, while the 143.5-point over/under has a 54% chance of going over.

 

Duke vs. Syracuse Odds

We have sourced the best College Basketball odds in America for this game, which are listed here:

Bet Type Duke Syracuse
Spread -17.5 (-108) +17.5 (-110)
Moneyline -2500 +1300
Total o143.5 (-110) u143.5 (-108)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Duke vs. Syracuse Picks and Best Bets

Our model's biggest edge in today's Duke vs. Syracuse matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Duke vs. Syracuse Game-Day Updates and Essential Details

Wednesday's college basketball action between Syracuse and Duke at JMA Wireless Dome is scheduled to begin at 7:00PM ET.

  • Who: Duke vs. Syracuse
  • Date: Wednesday, February 5, 2025
  • Time: 7:00PM ET/4:00PM PT
  • Venue: JMA Wireless Dome

Dimers.com's comprehensive preview of Wednesday's Duke vs. Syracuse matchup includes our prediction, picks and the latest betting odds.

Before making any Duke vs. Syracuse picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

Conclusion

We predict Duke, with a 94% win probability, will likely beat Syracuse on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Duke vs. Syracuse insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on College Basketball

Keep up with the latest college basketball betting news, college basketball best bets and CBB parlay picks throughout the season. Plus, our March Madness odds offer the latest probabilities for every March Madness contender.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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