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Duke vs. USF prediction: Duke favored to win women's college basketball matchup [11/20/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Duke vs USF predictions for college basketball Thursday.
Women's college basketball action continues on Thursday at 8:00PM ET as the favored Duke takes on USF at Yuengling Center.
Based on the latest simulation results, Dimers' new women's basketball model projects Duke as the most likely winner of the Duke vs. USF game.
This article offers further insights into Thursday's matchup, including best bets and picks.
Duke vs. USF prediction: Who will win?
Using powerful machine learning and data, we have simulated the result of Thursday's women's basketball matchup between Duke and USF 10,000 times as part of our women's college basketball predictions coverage.
Our independent predictive model gives Duke a 98% chance of beating South Florida.
According to our model, the 128.5-point over/under has a 60% chance of staying under.
Duke vs. USF odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Duke | USF |
|---|---|---|
| Spread | -14.5 (-110) | +14.5 (-110) |
| Moneyline | -1351 | +800 |
| Total | o128.5 (-110) | u128.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Duke vs. USF picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Duke -14.5 | -110 |
| Moneyline | Duke | -1351 |
| Total | Under 128.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Duke -14.5 at the spread.
Duke vs. USF game-day updates and essential details
Thursday's women's basketball game between USF and Duke at Yuengling Center is scheduled to begin at 8:00PM ET.
- Who: Duke vs. South Florida
- Date: Thursday, November 20, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: Yuengling Center
Conclusion
We predict Duke, with a 98% win probability, will likely beat South Florida on Thursday.
AI and automation have enhanced this article to quickly deliver accurate Duke vs. South Florida insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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