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Duke vs. Louisville prediction: Duke favored to win men's college basketball matchup [1/6/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Duke vs Louisville predictions for college basketball Tuesday.
Louisville and Duke will lock horns in men's college basketball action at KFC Yum! Center on Tuesday, starting at 7:00 PM ET.
Based on updated simulation results, Dimers' advanced college basketball model gives Duke a slight edge with a 52% win probability over Louisville.
This article offers further insights into Tuesday's Duke vs. Louisville matchup, including an expanded look at the predicted score, best bets and picks.
Duke vs. Louisville prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball matchup between Duke and Louisville 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model currently gives Duke a 52% chance of defeating Louisville. Our predicted score is Duke 80-80 Louisville.
According to our model, Duke (+1.5) has a 55% chance of covering the spread, while the over/under total of 161.5 points has a 51% chance of staying under.
While there is no way for a men's college basketball game to end in a tie, our prediction of 80-80 is based on each team's average score in the above-mentioned simulations of Duke vs. Louisville.
Duke vs. Louisville odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Duke | Louisville |
|---|---|---|
| Spread | +1.5 (-115) | -1.5 (-105) |
| Moneyline | -102 | -104 |
| Total | o161.5 (-105) | u161.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Duke vs. Louisville picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Duke +1.5 | -115 |
| Moneyline | Duke | -102 |
| Total | Under 161.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Duke to win.
Duke vs. Louisville game-day updates and essential details
Tuesday's men's college basketball game between Louisville and Duke at KFC Yum! Center is scheduled to start at 7:00 PM ET.
- Who: Duke vs. Louisville
- Date: Tuesday, January 6, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict Duke, with a 52% win probability, will likely beat Louisville on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate Duke vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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