Drake vs. Southern Illinois prediction: Southern Illinois favored to win men's college basketball matchup [1/14/2026]

Men's college basketball action continues on Wednesday at 8:00 PM ET as Drake squares off with Southern Illinois in men's college basketball action at Banterra Center.

Based on updated simulations, Dimers' proven college basketball model predicts Southern Illinois as the most likely winner of the Drake vs. Southern Illinois game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Drake vs. Southern Illinois prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between Drake and Southern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Southern Illinois a 71% chance of defeating Drake. Our predicted final score has Southern Illinois winning 76-71.

According to our model, the bookmakers have got it right, and Drake and Southern Illinois each have a 50% chance of covering the spread, while the 144.5-point over/under has a 53% chance of going over.

Drake vs. Southern Illinois odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Drake vs. Southern Illinois picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Over 144.5 total points.

Drake vs. Southern Illinois game-day updates and essential details

Wednesday's men's college basketball matchup between Southern Illinois and Drake at Banterra Center is scheduled to commence at 8:00 PM ET.

• Who: Drake vs. Southern Illinois
• Date: Wednesday, January 14, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Banterra Center

Conclusion

We predict Southern Illinois, with a 71% win probability, will likely beat Drake on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Drake vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.