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Pistons vs. Trail Blazers prediction: Why Detroit is favored to win Monday's NBA game [12/22/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Detroit Pistons vs Portland Trail Blazers predictions for NBA Monday.
The Portland Trail Blazers will take on the favored Detroit Pistons in NBA action at Moda Center on Monday, starting at 10:00 PM ET.
Based on the latest simulation results and today’s injury updates, Dimers' proven NBA model projects the Pistons as the most likely winner of the Pistons vs. Trail Blazers game.
This prediction follows the latest NBA Injury Report, which suggests the Trail Blazers lineup will feature players like Deni Avdija, Shaedon Sharpe and Jerami Grant, while the Pistons will look to Cade Cunningham, Jalen Duren and Tobias Harris.
This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Pistons vs. Blazers prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Monday's NBA game between the Pistons and Trail Blazers 10,000 times as part of our NBA predictions coverage.
Our independent predictive model currently gives the Pistons a 67% chance of defeating the Trail Blazers. Our predicted final score has the Pistons winning 119-114.
According to our model, the Trail Blazers (+6) have a 52% chance of covering the spread, while the 234.5-point over/under has a 51% chance of staying under.
Pistons vs. Trail Blazers odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Pistons | Trail Blazers |
|---|---|---|
| Spread | -6 (-106) | +6 (-114) |
| Moneyline | -235 | +195 |
| Total | o234.5 (-110) | u234.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Pistons vs. Trail Blazers picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Trail Blazers +6 | -114 |
| Moneyline | Trail Blazers | +195 |
| Total | Under 234.5 | -105 |
According to our best NBA bets for Monday, the top play to make on this game is Under 234.5 total points.
Pistons vs. Trail Blazers player props
NBA prop bets are a popular way to wager on the Pistons vs. Trail Blazers matchup without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Moda Center.
Cade Cunningham is expected to lead the Pistons with 28 points, 6 rebounds and 9 assists, while Deni Avdija is projected to have 26 points, 8 rebounds and 6 assists for the Trail Blazers.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
Pistons prediction
Our model's projected player stats for the Pistons are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Cade Cunningham | 28 | 6 | 9 | 2 | 58 |
| Jalen Duren | 17 | 10 | 3 | 0 | 39 |
| Tobias Harris | 13 | 5 | 2 | 1 | 26 |
| Ausar Thompson | 12 | 6 | 3 | 0 | 28 |
| Duncan Robinson | 11 | 3 | 2 | 2 | 21 |
Trail Blazers prediction
Projected points, rebounds, assists and three-pointers made for the Trail Blazers:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Deni Avdija | 26 | 8 | 6 | 2 | 51 |
| Shaedon Sharpe | 23 | 5 | 3 | 2 | 40 |
| Jerami Grant | 18 | 4 | 3 | 3 | 33 |
| Toumani Camara | 14 | 5 | 3 | 3 | 31 |
| Donovan Clingan | 10 | 11 | 2 | 1 | 32 |
Pistons vs. Blazers game-day updates and essential details
Monday's matchup between the Trail Blazers and Pistons at Moda Center is scheduled to start at 10:00 PM ET.
- Who: Detroit Pistons vs. Portland Trail Blazers
- Date: Monday, December 22, 2025
- Time: 10:00 PM ET/7:00PM PT
- Venue: Moda Center
Conclusion
We predict the Pistons, with a 67% win probability, will likely beat the Trail Blazers on Monday, with Cade Cunningham projected for a game-high 58 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Pistons vs. Trail Blazers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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