Pistons vs. Trail Blazers prediction: Why Detroit is favored to win Monday's NBA game [12/22/2025]

The Portland Trail Blazers and Detroit Pistons will lock horns in NBA action at Moda Center on Monday, with tipoff at 10:00 PM ET.

Based on the latest simulation results and today’s injury news, Dimers' proven NBA model projects the Pistons as the most likely winner of the Pistons vs. Trail Blazers game.

This prediction follows the latest NBA Injury Report, which suggests the Trail Blazers lineup will feature players like Deni Avdija, Shaedon Sharpe and Toumani Camara, while the Pistons will be led by Cade Cunningham, Jalen Duren and Tobias Harris.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Pistons vs. Blazers prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Monday's NBA matchup between the Pistons and Trail Blazers 10,000 times as part of our NBA predictions coverage.

Our leading predictive model currently gives the Pistons a 69% chance of beating the Trail Blazers. Our predicted final score has the Pistons winning 120-114.

According to our model, the Trail Blazers (+6) have a 53% chance of covering the spread, while the 234.5-point over/under has a 51% chance of staying under.

Pistons vs. Trail Blazers odds

We have researched the best NBA odds in America for this game, which are listed here:

Bet Type	Pistons	Trail Blazers
Spread	-6 (-112)	+6 (-108)
Moneyline	-235	+205
Total	o234.5 (-110)	u234.5 (-108)

All odds are correct at the time of publication and are subject to change.

Pistons vs. Trail Blazers picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Trail Blazers +6	-108
Moneyline	Pistons	-235
Total	Under 234.5	-108

According to our best NBA bets for Monday, the top play to make on this game is Trail Blazers +6 at the spread.

Pistons vs. Trail Blazers player props

NBA prop bets are a common way to wager on the Pistons vs. Trail Blazers game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Moda Center.

Cade Cunningham is expected to lead the Pistons with 28 points, 6 rebounds and 9 assists, while Deni Avdija is projected to have 26 points, 8 rebounds and 6 assists for the Trail Blazers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Pistons prediction

Our model's projected player stats for the Pistons are:

Player	PTS	REB	AST	3PM	DFS
Cade Cunningham	28	6	9	2	57
Jalen Duren	17	10	3	0	40
Tobias Harris	14	5	2	1	28
Ausar Thompson	12	6	3	0	28
Duncan Robinson	11	3	2	3	22

Trail Blazers prediction

Projected points, rebounds, assists and three-pointers made for the Trail Blazers:

Player	PTS	REB	AST	3PM	DFS
Deni Avdija	26	8	6	2	52
Shaedon Sharpe	25	5	3	2	42
Toumani Camara	14	5	3	3	32
Donovan Clingan	10	11	2	1	33
Sidy Cissoko	8	4	2	1	19

Pistons vs. Blazers game-day updates and essential details

Monday's game between the Trail Blazers and Pistons at Moda Center is scheduled to begin at 10:00 PM ET.

• Who: Detroit Pistons vs. Portland Trail Blazers
• Date: Monday, December 22, 2025
• Time: 10:00 PM ET/7:00PM PT
• Venue: Moda Center

Conclusion

We predict the Pistons, with a 69% win probability, will likely beat the Trail Blazers on Monday, with Cade Cunningham projected for a game-high 57 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Pistons vs. Trail Blazers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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