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Pistons vs. Bulls prediction: Why Detroit is favored to win Wednesday's NBA matchup [10/22/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Detroit Pistons vs Chicago Bulls predictions for NBA Wednesday.
The Chicago Bulls will square off with the Detroit Pistons in NBA action at United Center on Wednesday, beginning at 8:00PM ET.
Based on updated simulations and today’s injury reports, Dimers' advanced NBA model projects the Pistons as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Pistons-Bulls game 10,000 times," said Damien Souness from Dimers.
"With the latest updates and numerous other variables, we estimate the Pistons' chance of winning at 61%, with the Bulls at 39%."
This prediction follows the latest NBA Injury Report, which suggests the Bulls lineup will feature players like Nikola Vucevic, Josh Giddey and Matas Buzelis, while the Pistons will rely on Cade Cunningham, Jalen Duren and Ausar Thompson.
For expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive Pistons vs. Bulls predictions page.
Pistons vs. Bulls prediction: Who will win, cover the spread?
Using powerful machine learning and data analysis, we have simulated the result of Wednesday's NBA matchup between the Pistons and Bulls 10,000 times as part of our NBA predictions coverage.
Our leading predictive model gives the Pistons a 61% chance of beating the Bulls. Our predicted final score has the Pistons winning 119-116.
According to our model, the Pistons (-3.5) have a 51% chance of covering the spread, while the 236.5-point over/under has a 54% chance of staying under.
Pistons vs. Bulls odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | Pistons | Bulls |
|---|---|---|
| Spread | -3.5 (-105) | +3.5 (-108) |
| Moneyline | -155 | +150 |
| Total | o236.5 (-110) | u236.5 (-108) |
All odds are correct at the time of publication and are subject to change.
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Pistons vs. Bulls picks and best bets
Our model's strongest edge in today's Pistons vs. Bulls matchup is on the spread.
Our expert predictions, aligned with the best odds, reveal the best NBA picks and NBA best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Pistons vs. Bulls player props
Looking for Pistons vs. Bulls NBA prop bets? We have crunched the numbers to project how each team's leading players will perform at United Center.
Cade Cunningham is expected to lead the Pistons in scoring, while Nikola Vucevic is projected to be the top scorer for the Bulls.
Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.
Pistons vs. Bulls game-day updates and essential details
Wednesday's action between the Bulls and Pistons at United Center is scheduled to begin at 8:00PM ET.
- Who: Detroit Pistons vs. Chicago Bulls
- Date: Wednesday, October 22, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: United Center
Dimers' in-depth preview of Wednesday's Pistons vs. Bulls matchup includes our prediction, picks and the latest betting odds.
Before making any Pistons vs. Bulls picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.
Conclusion
We predict the Pistons, with a 61% win probability, will likely beat the Bulls on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Pistons vs. Bulls insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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