DePaul vs. Villanova prediction: Villanova favored to win men's college basketball matchup [12/31/2025]

Villanova will take on DePaul in men's college basketball action at The William B. Finneran Pavilion on Wednesday, starting at 6:00 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts Villanova as the most likely winner of the DePaul vs. Villanova game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

DePaul vs. Villanova prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between DePaul and Villanova 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Villanova a 91% chance of beating DePaul. Our predicted final score has Villanova winning 76-62.

According to our model, the bookies have got it right, and DePaul and Villanova each have a 50% chance of covering the spread, while the 138.5-point over/under has a 52% chance of going over.

DePaul vs. Villanova odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

DePaul vs. Villanova picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: