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DePaul vs. St. John's prediction: St. John's favored to win men's college basketball matchup [12/16/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get DePaul vs St. John's predictions for college basketball Tuesday.
St. John's will square off with DePaul in men's college basketball action at Carnesecca Arena on Tuesday, beginning at 7:00 PM ET.
Based on the latest simulations, Dimers' advanced college basketball model predicts St. John's as the most likely winner of the DePaul vs. St. John's game.
This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.
DePaul vs. St. John's prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the result of Tuesday's NCAA basketball matchup between DePaul and St. John's 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives St. John's a 96% chance of defeating DePaul. Our predicted final score has St. John's winning 85-64.
According to our model, St. John's (-19.5) has a 53% chance of covering the spread, while the 147.5-point over/under has a 52% chance of going over.
DePaul vs. St. John's odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | DePaul | St. John's |
|---|---|---|
| Spread | +19.5 (-110) | -19.5 (-110) |
| Moneyline | +1400 | -2400 |
| Total | o147.5 (-105) | u147.5 (-105) |
All odds are correct at the time of publication and are subject to change.
DePaul vs. St. John's picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | St. John's -19.5 | -110 |
| Moneyline | St. John's | -2400 |
| Total | Over 147.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Over 147.5 total points.
DePaul vs. St. John's game-day updates and essential details
Tuesday's men's college basketball action between St. John's and DePaul at Carnesecca Arena is scheduled to commence at 7:00 PM ET.
- Who: DePaul vs. St. John's
- Date: Tuesday, December 16, 2025
- Time: 7:00 PM ET/4:00PM PT
- Venue: Carnesecca Arena
Conclusion
We predict St. John's, with a 96% win probability, will likely beat DePaul on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate DePaul vs. St. John's insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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