DePaul vs. St. John's prediction: St. John's favored to win men's college basketball matchup [12/16/2025]

St. John's will face DePaul in men's college basketball action at Carnesecca Arena on Tuesday, starting at 7:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts St. John's as the most likely winner of the DePaul vs. St. John's game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

DePaul vs. St. John's prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the outcome of Tuesday's NCAA basketball game between DePaul and St. John's 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives St. John's a 96% chance of beating DePaul. Our predicted final score has St. John's winning 86-65.

According to our model, St. John's (-19.5) has a 53% chance of covering the spread, while the over/under total of 151.5 points has a 52% chance of going over.

DePaul vs. St. John's odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

DePaul vs. St. John's picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: