DePaul vs. Seton Hall prediction: Seton Hall favored to win men's college basketball matchup [2/18/2026]

Seton Hall will face DePaul in men's college basketball action at Prudential Center on Wednesday, beginning at 8:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model projects Seton Hall as the most likely winner of the DePaul vs. Seton Hall game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

DePaul vs. Seton Hall prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between DePaul and Seton Hall 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Seton Hall a 77% chance of beating DePaul. Our predicted final score has Seton Hall winning 69-62.

According to our model, DePaul (+7.5) has a 55% chance of covering the spread, while the over/under total of 129.5 points has a 53% chance of going over.

DePaul vs. Seton Hall odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

DePaul vs. Seton Hall picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is DePaul +7.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

DePaul vs. Seton Hall game-day updates and essential details

Wednesday's men's college basketball action between Seton Hall and DePaul at Prudential Center is scheduled to start at 8:00 PM ET.

• Who: DePaul vs. Seton Hall
• Date: Wednesday, February 18, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Prudential Center

Conclusion

We predict Seton Hall, with a 77% win probability, will likely beat DePaul on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate DePaul vs. Seton Hall insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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