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DePaul vs. LSU prediction: LSU favored to win men's college basketball matchup [11/29/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get DePaul vs LSU predictions for college basketball Saturday.
LSU will take on DePaul in men's college basketball action at Raider Arena on Saturday, commencing at 7:00PM ET.
Based on updated simulations, Dimers' advanced college basketball model projects LSU as the most likely winner of the DePaul vs. LSU game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
DePaul vs. LSU prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Saturday's NCAA basketball game between DePaul and LSU 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives LSU a 62% chance of beating DePaul. Our predicted final score has LSU winning 77-74.
According to our model, DePaul (+5.5) has a 57% chance of covering the spread, while the 152.5-point over/under has a 53% chance of staying under.
DePaul vs. LSU odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | DePaul | LSU |
|---|---|---|
| Spread | +5.5 (-102) | -5.5 (-115) |
| Moneyline | +230 | -245 |
| Total | o152.5 (-112) | u152.5 (-105) |
All odds are correct at the time of publication and are subject to change.
DePaul vs. LSU picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | DePaul +5.5 | -102 |
| Moneyline | DePaul | +230 |
| Total | Under 152.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is DePaul to win.
DePaul vs. LSU game-day updates and essential details
Saturday's men's college basketball action between LSU and DePaul at Raider Arena is scheduled to start at 7:00PM ET.
- Who: DePaul vs. LSU
- Date: Saturday, November 29, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: Raider Arena
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Conclusion
We predict LSU, with a 62% win probability, will likely beat DePaul on Saturday.
AI and automation have enhanced this article to quickly deliver accurate DePaul vs. LSU insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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