DePaul vs. UConn prediction: Why Connecticut is favored to win men's college basketball matchup [1/10/2026]

Men's college basketball action continues on Saturday at 12:30 PM ET as DePaul takes on the favored UConn in men's college basketball action at PeoplesBank Arena.

Based on updated simulations, Dimers' proven college basketball model projects Connecticut as the most likely winner of the DePaul vs. UConn game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

DePaul vs. UConn prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between DePaul and UConn 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Connecticut a 97% chance of defeating DePaul. Our predicted final score has Connecticut winning 80-59.

According to our model, Connecticut (-19.5) has a 52% chance of covering the spread, while the 137.5-point over/under has a 55% chance of going over.

DePaul vs. UConn odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

DePaul vs. UConn picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: