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DePaul vs. Butler prediction: Butler favored to win men's college basketball matchup [1/20/2026]

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Written by Dave Garofolo

Get DePaul vs Butler predictions for college basketball Tuesday.

DePaul-Butler Predictions and Game Preview.
DePaul vs. Butler men's college basketball prediction for Tuesday, January 20, 2026.

Men's college basketball action continues on Tuesday at 7:30 PM ET as DePaul takes on the favored Butler in men's college basketball action at Hinkle Fieldhouse.

Based on the latest simulation results, Dimers' advanced college basketball model projects Butler as the most likely winner of the DePaul vs. Butler game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

DePaul vs. Butler prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's NCAA basketball matchup between DePaul and Butler 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Butler a 75% chance of defeating DePaul. Our predicted final score has Butler winning 79-72.

According to our model, DePaul (+7.5) has a 52% chance of covering the spread, while the 147.5-point over/under has a 55% chance of going over.

 

DePaul vs. Butler odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type DePaul Butler
Spread +7.5 (-115) -7.5 (-105)
Moneyline +290 -325
Total o147.5 (-115) u147.5 (-105)

All odds are correct at the time of publication and are subject to change.

DePaul vs. Butler picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread DePaul +7.5 -115
Moneyline DePaul +290
Total Over 147.5 -115

According to our men's college basketball best bets, the top play to make on this game is Over 147.5 total points.

 

DePaul vs. Butler game-day updates and essential details

Tuesday's men's college basketball matchup between Butler and DePaul at Hinkle Fieldhouse is scheduled to commence at 7:30 PM ET.

  • Who: DePaul vs. Butler
  • Date: Tuesday, January 20, 2026
  • Time: 7:30 PM ET/4:30PM PT
  • Venue: Hinkle Fieldhouse

Conclusion

We predict Butler, with a 75% win probability, will likely beat DePaul on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate DePaul vs. Butler insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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