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Creighton vs. Xavier prediction: Xavier favored to win men's college basketball matchup [12/17/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Creighton vs Xavier predictions for college basketball Wednesday.
Xavier will face Creighton in men's college basketball action at Cintas Center on Wednesday, starting at 6:30 PM ET.
Based on updated simulations, Dimers' proven college basketball model predicts Xavier as the most likely winner of the Creighton vs. Xavier game.
This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Creighton vs. Xavier prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's NCAA basketball game between Creighton and Xavier 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Xavier a 62% chance of defeating Creighton. Our predicted final score has Xavier winning 77-73.
According to our model, Xavier (-2.5) has a 54% chance of covering the spread, while the 151.5-point over/under has a 53% chance of staying under.
Creighton vs. Xavier odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Creighton | Xavier |
|---|---|---|
| Spread | +2.5 (-102) | -2.5 (-118) |
| Moneyline | +136 | -160 |
| Total | o151.5 (-115) | u151.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Creighton vs. Xavier picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Xavier -2.5 | -118 |
| Moneyline | Xavier | -160 |
| Total | Under 151.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Under 151.5 total points.
Creighton vs. Xavier game-day updates and essential details
Wednesday's men's college basketball action between Xavier and Creighton at Cintas Center is scheduled to start at 6:30 PM ET.
- Who: Creighton vs. Xavier
- Date: Wednesday, December 17, 2025
- Time: 6:30 PM ET/3:30PM PT
- Venue: Cintas Center
Conclusion
We predict Xavier, with a 62% win probability, will likely beat Creighton on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Creighton vs. Xavier insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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