Creighton vs. Xavier prediction: Xavier favored to win men's college basketball matchup [12/17/2025]

Xavier will face Creighton in men's college basketball action at Cintas Center on Wednesday, commencing at 6:30 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Xavier as the most likely winner of the Creighton vs. Xavier game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Creighton vs. Xavier prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Creighton and Xavier 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Xavier a 61% chance of defeating Creighton. Our predicted final score has Xavier winning 76-73.

According to our model, Xavier (-2.5) has a 51% chance of covering the spread, while the over/under total of 149.5 points has a 52% chance of staying under.

Creighton vs. Xavier odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Creighton vs. Xavier picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: