Creighton vs. Villanova prediction: Villanova favored to win men's college basketball matchup [1/7/2026]

Men's college basketball action continues on Wednesday at 7:30 PM ET as Creighton takes on the favored Villanova in men's college basketball action at The William B. Finneran Pavilion.

Based on updated simulation results, Dimers' advanced college basketball model predicts Villanova as the most likely winner of the Creighton vs. Villanova game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Creighton vs. Villanova prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's NCAA basketball game between Creighton and Villanova 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Villanova a 65% chance of defeating Creighton. Our predicted final score has Villanova winning 74-70.

According to our model, Creighton (+4.5) has a 51% chance of covering the spread, while the over/under total of 142.5 points has a 51% chance of going over.

Creighton vs. Villanova odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Creighton vs. Villanova picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: