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UConn vs. DePaul prediction: Connecticut favored to win men's college basketball matchup [12/21/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get UConn vs DePaul predictions for college basketball Sunday.
DePaul will square off with the favored UConn in men's college basketball action at Wintrust Arena on Sunday, beginning at 4:30 PM ET.
Based on the latest simulations, Dimers' proven college basketball model predicts Connecticut as the most likely winner of the UConn vs. DePaul game.
This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.
UConn vs. DePaul prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Sunday's NCAA basketball game between UConn and DePaul 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Connecticut an 86% chance of defeating DePaul. Our predicted final score has Connecticut winning 75-64.
According to our model, DePaul (+12.5) has a 56% chance of covering the spread, while the over/under total of 133.5 points has a 56% chance of going over.
UConn vs. DePaul odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | UConn | DePaul |
|---|---|---|
| Spread | -12.5 (-110) | +12.5 (-110) |
| Moneyline | -580 | +650 |
| Total | o133.5 (-110) | u133.5 (-110) |
All odds are correct at the time of publication and are subject to change.
UConn vs. DePaul picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | DePaul +12.5 | -110 |
| Moneyline | Connecticut | -580 |
| Total | Over 133.5 | -110 |
According to our best men's college basketball bets, the top play to make on this game is Over 133.5 total points.
UConn vs. DePaul game-day updates and essential details
Sunday's men's college basketball matchup between DePaul and UConn at Wintrust Arena is scheduled to commence at 4:30 PM ET.
- Who: Connecticut vs. DePaul
- Date: Sunday, December 21, 2025
- Time: 4:30 PM ET/1:30PM PT
- Venue: Wintrust Arena
Conclusion
We predict Connecticut, with an 86% win probability, will likely beat DePaul on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Connecticut vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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