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Colorado vs. Louisville prediction: Louisville favored to win women's college basketball matchup [11/12/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Colorado vs Louisville predictions for college basketball Wednesday.
Women's college basketball action continues on Wednesday at 7:00PM ET as Colorado faces off with the favored Louisville at KFC Yum! Center.
Based on the latest simulation results, Dimers' new women's basketball model projects Louisville as the most likely winner of the Colorado vs. Louisville game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Colorado vs. Louisville prediction: Who will win?
Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's women's basketball game between Colorado and Louisville 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model currently gives Louisville an 83% chance of defeating Colorado.
According to our model, the 134.5-point over/under has a 51% chance of staying under.
Colorado vs. Louisville odds
We have sourced the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Colorado | Louisville |
|---|---|---|
| Spread | +10.5 (-110) | -10.5 (-106) |
| Moneyline | +470 | -599 |
| Total | o134.5 (-110) | u134.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Colorado vs. Louisville picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Colorado +10.5 | -110 |
| Moneyline | Colorado | +470 |
| Total | Under 134.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Colorado +10.5 at the spread.
Colorado vs. Louisville game-day updates and essential details
Wednesday's women's basketball matchup between Louisville and Colorado at KFC Yum! Center is scheduled to commence at 7:00PM ET.
- Who: Colorado vs. Louisville
- Date: Wednesday, November 12, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict Louisville, with an 83% win probability, will likely beat Colorado on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Colorado vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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