Guardians vs. Nationals Prediction: Cleveland Predicted to Win Wednesday's MLB Matchup [5/7/2025]

The Washington Nationals will take on the Cleveland Guardians in MLB action at Nationals Park on Wednesday, starting at 12:05PM ET.

Michael Soroka (0-1, 7.20 ERA) will be the starting pitcher for the Nationals, up against Logan Allen (1-2, 4.02 ERA) for the Guardians.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cleveland-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 53%, with the Nationals at 47%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Nationals predictions page.

Nationals vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Guardians and Nationals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Guardians a 53% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 59% chance of covering the run line, while the 9.5-run over/under has a 57% chance of staying under.

Guardians vs. Nationals Odds [5/7/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Nationals
Run Line	-1.5 (+140)	+1.5 (-156)
Moneyline	-110	+100
Total	o9.5 (+102)	u9.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Nationals Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Nationals matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Guardians vs. Nationals Game-Day Updates and Essential Details

Wednesday's MLB action between the Nationals and Guardians at Nationals Park is scheduled to commence at 12:05PM ET.

• Who: Cleveland Guardians vs. Washington Nationals
• Date: Wednesday, May 7, 2025
• Time: 12:05PM ET/9:05AM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Wednesday's Guardians vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 53% win probability, will likely beat the Nationals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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