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Cavaliers vs. 76ers prediction: Philadelphia to win, Donovan Mitchell projected for big game in Friday's NBA matchup [1/16/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Cleveland Cavaliers vs Philadelphia 76ers predictions for NBA Friday.
The Philadelphia 76ers will face the Cleveland Cavaliers in NBA action at Xfinity Mobile Arena on Friday, commencing at 7:00 PM ET.
Based on the latest simulation results and today’s injury reports, Dimers' proven NBA model predicts the 76ers as the most likely winner of the Cavaliers vs. 76ers game.
This prediction follows the latest NBA Injury Report, which suggests the 76ers lineup will feature players like Tyrese Maxey, Joel Embiid and Paul George, while the Cavaliers will be led by Donovan Mitchell, Evan Mobley and Jarrett Allen.
This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Sixers vs. Sixers prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Friday's NBA matchup between the Cavaliers and 76ers 10,000 times as part of our NBA predictions coverage.
Our independent predictive model currently gives the 76ers a 60% chance of beating the Cavaliers. Our predicted final score has the 76ers winning 116-113.
According to our model, the 76ers (-2.5) have a 51% chance of covering the spread, while the 233.5-point over/under has a 55% chance of staying under.
Cavaliers vs. 76ers odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Cavaliers | 76ers |
|---|---|---|
| Spread | +2.5 (-105) | -2.5 (-108) |
| Moneyline | +124 | -138 |
| Total | o233.5 (-105) | u233.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Cavaliers vs. 76ers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 76ers -2.5 | -108 |
| Moneyline | 76ers | -138 |
| Total | Under 233.5 | -115 |
According to our best NBA bets for Friday, the top play to make on this game is Under 233.5 total points.
Cavaliers vs. 76ers player props
Betting on Cleveland vs. Philadelphia NBA player props? We use the best information available to project how each team's leading players will perform at Xfinity Mobile Arena.
Donovan Mitchell is expected to lead the Cavaliers with 31 points, 5 rebounds and 6 assists, while Tyrese Maxey is projected to have 26 points, 4 rebounds and 7 assists for the 76ers.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
Cavaliers prediction
Our model's projected player stats for the Cavaliers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| D. Mitchell | 31 | 5 | 6 | 4 | 54 |
| Evan Mobley | 19 | 9 | 4 | 2 | 43 |
| Jarrett Allen | 16 | 9 | 2 | 0 | 36 |
| Jaylon Tyson | 14 | 6 | 3 | 2 | 31 |
| De'Andre Hunter | 14 | 4 | 2 | 2 | 25 |
76ers prediction
Projected points, rebounds, assists and three-pointers made for the 76ers:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Tyrese Maxey | 26 | 4 | 7 | 3 | 48 |
| Joel Embiid | 25 | 9 | 4 | 2 | 51 |
| Paul George | 17 | 5 | 4 | 3 | 36 |
| VJ Edgecombe | 15 | 5 | 5 | 2 | 35 |
| Quentin Grimes | 13 | 3 | 4 | 2 | 27 |
Cavs vs. Sixers game-day updates and essential details
Friday's game between the 76ers and Cavaliers at Xfinity Mobile Arena is scheduled to begin at 7:00 PM ET.
- Who: Cleveland Cavaliers vs. Philadelphia 76ers
- Date: Friday, January 16, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: Xfinity Mobile Arena
Conclusion
We predict the 76ers, with a 60% win probability, will likely beat the Cavaliers on Friday, with Donovan Mitchell projected for a game-high 54 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. 76ers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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