Cavaliers vs. 76ers prediction: Philadelphia to win, Donovan Mitchell projected for big game in Friday's NBA matchup [1/16/2026]

NBA action continues on Friday at 7:00 PM ET as the Cleveland Cavaliers lock horns with the Philadelphia 76ers at Xfinity Mobile Arena.

Based on updated simulation results and today’s injury updates, Dimers' proven NBA model predicts the 76ers as the most likely winner of the Cavaliers vs. 76ers game.

This prediction follows the latest NBA Injury Report, which suggests the 76ers lineup will feature players like Tyrese Maxey, Joel Embiid and Paul George, while the Cavaliers will be led by Donovan Mitchell, Evan Mobley and Jarrett Allen.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Sixers vs. Sixers prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Friday's NBA matchup between the Cavaliers and 76ers 10,000 times as part of our NBA predictions coverage.

Our independent predictive model gives the 76ers a 60% chance of defeating the Cavaliers. Our predicted final score has the 76ers winning 116-113.

According to our model, the 76ers (-2.5) have a 51% chance of covering the spread, while the over/under total of 233.5 points has a 55% chance of staying under.

Cavaliers vs. 76ers odds

We have researched the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Cavaliers vs. 76ers picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Friday, the top play to make on this game is Under 233.5 total points.

Cavaliers vs. 76ers player props

Betting on Cleveland vs. Philadelphia NBA prop bets? We use the best information available to project how each team's leading players will perform at Xfinity Mobile Arena.

Donovan Mitchell is expected to lead the Cavaliers with 30 points, 5 rebounds and 6 assists, while Tyrese Maxey is projected to have 27 points, 4 rebounds and 7 assists for the 76ers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Cavaliers prediction

Our model's projected player stats for the Cavaliers are:

76ers prediction

Projected points, rebounds, assists and three-pointers made for the 76ers:

Cavs vs. Sixers game-day updates and essential details

Friday's action between the 76ers and Cavaliers at Xfinity Mobile Arena is scheduled to commence at 7:00 PM ET.

• Who: Cleveland Cavaliers vs. Philadelphia 76ers
• Date: Friday, January 16, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Xfinity Mobile Arena

Conclusion

We predict the 76ers, with a 60% win probability, will likely beat the Cavaliers on Friday, with Donovan Mitchell projected for a game-high 52 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. 76ers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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