...
...
Read Article
- More Betting
Cavaliers vs. Knicks prediction: Cleveland to win, Donovan Mitchell projected for big game in Wednesday's NBA matchup [10/22/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Cleveland Cavaliers vs New York Knicks predictions for NBA Wednesday.
The New York Knicks and Cleveland Cavs will meet in NBA action at Madison Square Garden on Wednesday, starting at 7:00PM ET.
Based on updated simulations and today’s injury news, Dimers' proven NBA model predicts the Cavaliers as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Cavaliers-Knicks game 10,000 times," said Damien Souness from Dimers.
"With the latest updates and numerous other variables, we estimate the Cavaliers' chance of winning at 53%, with the Knicks at 47%."
This prediction follows the latest NBA Injury Report, which suggests the Knicks lineup will feature players like Jalen Brunson, Karl-Anthony Towns and OG Anunoby, while the Cavaliers will look to Donovan Mitchell, Evan Mobley and Jarrett Allen.
For a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive Cavaliers vs. Knicks predictions page.
Cavs vs. Knicks prediction: Who will win, cover the spread?
Using trusted machine learning and data, we have simulated the outcome of Wednesday's NBA matchup between the Cavaliers and Knicks 10,000 times as part of our NBA predictions coverage.
Our famous predictive model currently gives the Cavaliers a 53% chance of beating the Knicks. Our predicted score is Cavaliers 114-114 Knicks.
According to our model, the Knicks (+1.5) have a 53% chance of covering the spread, while the over/under total of 228.5 points has an equal 50-50 chance of hitting.
While there is no way for an NBA game to end in a tie, our prediction of 114-114 is based on each team's average score in the above-mentioned simulations of Cavaliers vs. Knicks.
Cavaliers vs. Knicks odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Cavaliers | Knicks |
|---|---|---|
| Spread | -1.5 (-110) | +1.5 (-105) |
| Moneyline | -120 | +105 |
| Total | o228.5 (-115) | u228.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Boost your NBA betting by exploring the latest NBA betting promos, sourced from top sportsbooks and DFS operators.
Cavaliers vs. Knicks picks and best bets
Our model's strongest edge in today's Cavaliers vs. Knicks matchup is on the total.
Our expert predictions, aligned with the best odds, reveal the best NBA picks and NBA best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Cavaliers vs. Knicks player props
NBA prop bets are an exciting way to wager on the Cleveland vs. New York game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Madison Square Garden.
Donovan Mitchell is expected to lead the Cavaliers in scoring, while Jalen Brunson is projected to be the top scorer for the Knicks.
Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.
Cavs vs. Knicks game-day updates and essential details
Wednesday's action between the Knicks and Cavaliers at Madison Square Garden is scheduled to begin at 7:00PM ET.
- Who: Cleveland Cavaliers vs. New York Knicks
- Date: Wednesday, October 22, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: Madison Square Garden
Dimers' full preview of Wednesday's Cavaliers vs. Knicks matchup includes our prediction, picks and the latest betting odds.
Before making any Cavs vs. Knicks picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.
Conclusion
We predict the Cavaliers, with a 53% win probability, will likely beat the Knicks on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. Knicks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
More on NBA
Keep up with the latest NBA betting news and NBA parlay picks throughout the season. Plus, our NBA championship odds offer the latest projections for the NBA title.
Boost your NBA betting by exploring the latest NBA betting promos, sourced from top sportsbooks and DFS operators.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
Advertiser disclosure