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Cavaliers vs. Celtics prediction: Cleveland to win, Donovan Mitchell projected for 27 points in Wednesday's NBA game [10/29/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Cleveland Cavaliers vs Boston Celtics predictions for NBA Wednesday.
The Boston Celtics will square off with the Cleveland Cavaliers in NBA action at TD Garden on Wednesday, starting at 7:00PM ET.
Based on updated simulation results and today’s injury news, Dimers' advanced NBA model projects the Cavaliers as the most likely winner of the Cavaliers vs. Celtics game.
This prediction follows the latest NBA Injury Report, which suggests the Celtics lineup will feature stars like Jaylen Brown, Derrick White and Payton Pritchard, while the Cavaliers will be led by Donovan Mitchell, Evan Mobley and De'Andre Hunter.
This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Cavs vs. Celtics prediction: Who will win, cover the spread?
Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NBA matchup between the Cavaliers and Celtics 10,000 times as part of our NBA predictions coverage.
Our independent predictive model gives the Cavaliers a 66% chance of beating the Celtics. Our predicted final score has the Cavaliers winning 118-113.
According to our model, the Cavaliers (-4.5) have a 52% chance of covering the spread, while the 232.5-point over/under has a 52% chance of staying under.
Cavaliers vs. Celtics odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Cavaliers | Celtics |
|---|---|---|
| Spread | -4.5 (-105) | +4.5 (-110) |
| Moneyline | -180 | +160 |
| Total | o232.5 (-112) | u232.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Cavaliers vs. Celtics picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Cavaliers -4.5 | -105 |
| Moneyline | Cavaliers | -180 |
| Total | Under 232.5 | -108 |
According to our NBA best bets, the top play to make on this game is Cavaliers to win.
Cavaliers vs. Celtics player props
Betting on Cleveland vs. Boston NBA player props? We use the best information available to project how each team's leading players will perform at TD Garden.
Donovan Mitchell is expected to lead the Cavaliers with 27 points, 5 rebounds and 5 assists, while Jaylen Brown is projected to have 23 points, 6 rebounds and 4 assists for the Celtics.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.
Cavaliers prediction
Our model's projected player stats for the Cavaliers are:
| Player | PTS | REB | AST | 3PM |
|---|---|---|---|---|
| Donovan Mitchell | 27 | 5 | 5 | 3 |
| Evan Mobley | 18 | 10 | 3 | 1 |
| De'Andre Hunter | 15 | 4 | 2 | 2 |
| Jarrett Allen | 12 | 9 | 1 | 0 |
| Jaylon Tyson | 9 | 5 | 2 | 1 |
Celtics prediction
Projected points, rebounds, assists and three-pointers made for the Celtics:
| Player | PTS | REB | AST | 3PM |
|---|---|---|---|---|
| Jaylen Brown | 23 | 6 | 4 | 2 |
| Derrick White | 18 | 4 | 5 | 3 |
| Payton Pritchard | 16 | 4 | 4 | 3 |
| Anfernee Simons | 16 | 2 | 4 | 3 |
| Sam Hauser | 10 | 4 | 1 | 3 |
Cavs vs. Celtics game-day updates and essential details
Wednesday's matchup between the Celtics and Cavaliers at TD Garden is scheduled to commence at 7:00PM ET.
- Who: Cleveland Cavaliers vs. Boston Celtics
- Date: Wednesday, October 29, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: TD Garden
Conclusion
We predict the Cavaliers, with a 66% win probability, will likely beat the Celtics on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. Celtics insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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