Clemson vs. Wake Forest prediction: Why Clemson is favored to win men's college basketball matchup [2/18/2026]

Wake Forest will face Clemson in men's college basketball action at Lawrence Joel Veterans Memorial Coliseum on Wednesday, beginning at 7:00 PM ET.

Based on the latest simulations, Dimers' proven college basketball model predicts Clemson as the most likely winner of the Clemson vs. Wake Forest game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Clemson vs. Wake Forest prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between Clemson and Wake Forest 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Clemson a 65% chance of beating Wake Forest. Our predicted final score has Clemson winning 73-69.

According to our model, Wake Forest (+3.5) has a 51% chance of covering the spread, while the 140.5-point over/under has a 53% chance of going over.

Clemson vs. Wake Forest odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Clemson vs. Wake Forest picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: