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Clemson vs. South Carolina prediction: South Carolina favored to win in college football Week 14, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Clemson vs South Carolina predictions for college football Saturday.
South Carolina and Clemson will meet in Week 14 college football action at Williams-Brice Stadium on Saturday, with kickoff at 12:00PM ET.
Based on the latest simulation results, Dimers' advanced college football model projects South Carolina as the most likely winner of the Clemson vs. South Carolina game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Clemson vs. South Carolina prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Clemson vs. South Carolina 10,000 times as part of our college football predictions coverage.
Our famous predictive model currently gives South Carolina a 62% chance of beating Clemson. Our predicted final score has South Carolina winning 26-22.
According to our model, South Carolina (-2.5) has a 59% chance of covering the spread, while the 45.5-point over/under has a 54% chance of staying under.
Clemson vs. South Carolina odds
We have researched the best college football odds in America for this game, which are listed here:
| Bet Type | Clemson | South Carolina |
|---|---|---|
| Spread | +2.5 (-105) | -2.5 (-110) |
| Moneyline | +115 | -130 |
| Total | o45.5 (-114) | u45.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Clemson vs. South Carolina picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Carolina -2.5 | -110 |
| Moneyline | South Carolina | -130 |
| Total | Under 45.5 | -105 |
According to our best college football bets, the top play to make on this game is South Carolina -2.5 at the spread.
Clemson vs. South Carolina game-day updates and essential details
Saturday's college football action between South Carolina and Clemson at Williams-Brice Stadium is scheduled to start at 12:00PM ET.
- Who: Clemson vs. South Carolina
- Date: Saturday, November 29, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: Williams-Brice Stadium
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Conclusion
We predict South Carolina, with a 62% win probability, will likely beat Clemson on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Clemson vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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